MCS Featured Lab - March 2021
Song Hu, Ph.D.
Washington University in St. Louis
Our lab focuses on the development of cutting-edge optical and photoacoustic technologies for high-resolution structural, functional, metabolic, and molecular imaging in vivo. Our core technology, multi-parametric photoacoustic microscopy (PAM), is uniquely capable of simultaneously imaging hemoglobin concentration, blood oxygenation, and flow at the microscopic level. Combining multi-parametric PAM and segmentation-based single-vessel analysis, we have developed an unprecedented hardware-software platform for comprehensive and quantitative characterization of the microvasculature, including the structure, mechanical properties, hemodynamics, and associated tissue oxygen metabolism. This platform opens new opportunities to study the role of microvascular dysfunction in a wide spectrum of diseases, including neurovascular disorders, cancer, and cardiovascular diseases.
Top lesson you have learned in your career:
Be focused but open-minded
- N. Sun, B. Ning, A. Bruce, R. Cao, S. Seaman, T. Wang, R. Fritsche-Danielson, L. Carlsson, S. Peirce, S. Hu, In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network. Microcirculation. 2020 Apr;27(3):e12598. doi: 10.1111/micc.12598. Epub 2019 Dec 2 (PMID: 31660674)
- R. Cao, C. Zhang, V. Mitkin, M. Lankford, J. Li, Z. Zuo, C. Meyer, C. Goyne, S. Ahlers, J. Stone, S. Hu. BCR-ABL Tyrosine Kinase Inhibitors Promote Pathological Changes in Dilator Phenotype in the Human Microvasculature. J Neurotrauma. 2019 May 15;36(10):1526-1534. doi: 10.1089/neu.2018.6062. Epub 2019 Jan 25.(PMID: 30501547)
- R. Cao, J. Li, C. Zhang, Z. Zuo, S. Hu. Photoacoustic microscopy of obesity-induced cerebrovascular alterations. NeuroImage. 2019 Mar;188:369-379. doi: 10.1016/j.neuroimage.2018.12.027. Epub 2018 Dec 13. (PMID: 30553918)