MCS Featured Lab - January 2020

Research Description:

My research program has a longstanding interest in microvascular permeability and lymphatic functions. Our goal is to advance new therapeutics that can be used to reduce edema caused by traumatic injury or disease. Edema results from an imbalance between the degree of microvascular leakage of filtered plasma and the lymphatic uptake of interstitial fluid. Thus, our research has focused on targets that could be used therapeutically to: 1) prevention or reduction of microvascular hyperpermeability; and 2) increasing the capacity for lymphatic clearance. To approach these problems, we have focused on signaling mechanisms within and between cells, utilizing a combination of in vivo, isolated microvessel, and cultured endothelial cell models to study physiological endpoints. Our work has been funded by the NIH for the past twelve years and has primarily focused on signaling pathways that promote cytoskeletal and junctional rearrangements associated with enhanced barrier function.

Lab Website:

https://health.usf.edu/medicine/mpp/faculty/2846857/Breslin

Twitter:

https://twitter.com/JeromeBreslin

Top lesson you have learned in your career:

Opportunities present themselves more frequently as you gain more knowledge and mastery. Be ready for the next opportunity.

Recent Publications:

• Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. Lymphatic Vessel Network Structure and Physiology. Compr. Physiol. 9: 207-299, 2019. (PMID: 30549020)
• Jo M, Trujillo AN, Yang Y, Breslin JW. Evidence of Functional Ryanodine Receptors in Rat Mesenteric Collecting Lymphatic Vessels. Am. J. Physiol. Heart Circ. Physiol. 317: H561-H574, 2019. (PMID: 31274355 )
• Alves NG, Yuan SY, Breslin JW. Sphingosine-1-Phosphate Protects Against Brain Microvascular Endothelial Junctional Protein Disorganization and Barrier Function Caused by Alcohol. Microcirculation 26: e12506, 2019. (PMID: 30281888)