MCS Featured Lab -November 2019
Dr. Zhichao Fan, Ph.D.
Department of Immunology,
School of Medicine | UConn Health
Dr. Zhichao Fan’s laboratory research lies in the field of innate immunology and inflammation. Specifically, Dr. Fan’s lab focuses on the molecular mechanism of integrin activation on leukocyte adhesion during inflammatory diseases, including myocardial ischemia-reperfusion injury and cystic fibrosis, which they examine using advanced microscopy, including super-resolution single molecular microscopy, intravital microscopy, quantitative dynamic footprinting microscopy, and in vivo flow cytometry.
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- High affinity-bent β2 integrin molecules in arresting neutrophils face each other: role of binding to ICAMs in cis.Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, M. Arnaout A, Gutierrez E, Groisman A, Ginsberg MH, Ley K. Cell Reports. 2019; 26(1): 119-130. (PMID 30605669)
- Transmission of integrin β2 transmembrane domain topology regulates inside-out but not outside-in signaling. Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K.Journal of Leukocyte Biology. 2019; Epub ahead of print. (*co-first authors)
- Neutrophil recruitment limited by high affinity bent β2 integrin binding ligand in cis. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg MH, Groisman A, Ley K. Nature Communications. 2016; 7: 12658 (PMID: 27578049)