Microcirculatory Society .

The Microcirculatory Society Pre-Meeting Session at the American Physiology Summit 2023

MCS Pre-Meeting Sessions: April 20, 2023 8:00 AM - 4:00 PM

American Physiology Summit Sessions: April 20, 4:00 PM - April 23, 12:30 PM

MCS Pre-Meeting Program:

Thursday, April 20 - All MCS Symposia will be held in Ballroom II of the Long Beach Convention Center.

8:00 – 9:30: Emerging Topics in Microcirculation

Chairs: Erika Boerman (University of Missouri) and Andreas Beyer (Medical College of Wisconsin)

Capillary pericytes as metabolic sentinels in the control of brain blood flow. Tom Longden, University of Maryland School of Medicine
Modulation of the lymphatic vasculature in progression of liver pathogenesis. Sanjukta Chakraborty, Texas A&M University Health Science Center
3D Wall Shear Stress Characteristics in Angiogenic Microvascular Networks through Red Blood Cell-Resolved Modeling. Peter Balogh, New Jersey Institute of Technology
Perivascular adipose tissue drives vascular dysfunction in inflammatory bowel disease. Erika Boerman, University of Missouri
Renal lymphatics and their impact on kidney inflammation. Joseph Rutkowski, Texas A&M University Health Science Center

15-minute break

9:45 – 11:15: Gabor Kaley Award Featured Topic: Endothelial Cell Biology in Health and Disease

Chair: Patricia D’Amore

MiR-433-3p Inhibition Alleviates Increased Endothelial Cell Permeability in Diabetes. Anita Kovacs-Kasa, Augusta University Health
Impact of PCSK9 on endothelial efferocytosis in vascular aging. Zufeng Ding, University of Arkansas for Medical Sciences
The impact of aging on pulmonary microvascular endothelial cell barrier function. Aminmohamed Manji, Western University
Endothelial expression of iron transporters is dependent on contact with smooth muscle. Luke Dunaway, University of Virginia
Attenuated hyaluronan synthesis impairs glycocalyx integrity and leads to arterial dysfunction. Jisok Lim, University of Utah
Skeletal muscle-derived extracellular vesicles contribute to post-exercise hypotension. Anjali Bhat, University of Nebraska Medical Center

90-minute break for lunch

12:45 – 2:15: President’s Symposium: Micro-Lymphatics as Mediators of Tissue Homeostasis

Chairs: Jerome Breslin (University of South Florida) and Pooneh Bagher (University of Nebraska Medical Center)

The Role of Epsins and MiR22 in Lymphatic Development and Disease. Hong Chen, Harvard Medical School
Obesity and Lymphatic Dysfunction: Structural and Molecular Modifications. Jorge Castorena, Tulane University
Lymphatics, Blood Vessels, Tissue Engineering, and Cancer: Connections in the Microcirculation. W. Lee Murfee, University of Florida

15-minute break

2:30 - 4:00: MCS Trainee Flash Talks: The Microcirculation From Head to Toe

Chairs: Frankie Hu (University of Florida), Jamie Meegan (Vanderbilt University Medical Center), Reetu Singh (Texas A&M University), Liping Zhang (University of Missouri)

Presentations listed below. Speakers marked *.

Regulation of Blood-Brain Barrier Endothelial Cell Hyperpermeability by NLRP3 Inflammasome Inhibition - Aliyah Anderson* (Morehouse School of Medicine), O'lisa Yaa Waithe, Saravanakumar Muthusamy, Gabriela Seplovich, Oluwatoyin Olagunju, Binu Tharakan.
Role of potassium ion diffusion from neurons to capillaries in neurovascular coupling: effects of astrocytic endfeet geometry - Sara Djurich* (University of Arizona), Timothy Secomb.
Homocysteine-induced Barrier Dysfunction and Hyperpermeability in the Blood-Brain and Blood-Retinal Barrier: Role of NLRP3 Inflammasome Pathway - O'Lisa Yaa Waithe* (Morehouse School of Medicine), Saravanakumar Muthusamy, Aliyah Anderson, Travis Hein, Ed Childs, Binu Tharakan.
Regulation of endothelial cell mitochondrial phenotype by mechanosensitive ion channel TRPV4 - Kesha Dalal* (The University of Toledo), Venkatesh Katari, Sailaja Paruchuri, Charles Thodeti.
Upregulation of endothelial DRP1 promotes a pathological vasodilation mechanism in response to flow-induced dilation - Cristhian Gutierrez Huerta* (Medical College of Wisconsin), Erin Birch, Shelby Hader, Amanda LeBlanc, David Guterrman, Andreas Beyer.
Cell-free hemoglobin-mediated oxidation of low-density lipoprotein (oxLDL) contributes to lung microvascular endothelial dysfunction during sepsis - Jamie Meegan* (Vanderbilt University Medical Center), Lorraine Ware, Julie Bastarache.
Creating the Phenotype of Preeclamptic Endothelial Dysfunction in Placental Vessels - Rosinda De La Pena* (Medical College of Wisconsin), David Gutterman, Curt Sigmund, Jennifer McIntosh.
Three-Dimensional Shear Stress Characteristics in Angiogenic Microvascular Networks Revealed Through Red Blood Cell-Resolved Modeling Based on Real Image Data - Mir Md Nasim Hossain* (New Jersey Institute of Technology), Nien-Wen Hu, Walter Murfee, Peter Balogh.
Short-chain fatty acids of the intestinal microbiota reduce mesenteric lymphatic pumping - Reetu Singh* (Texas A&M University), Cristine Heaps, Mariappan Muthuchamy, Randolph Stewart, Glen Laine, Ranjeet Dongaonkar.
Microvascular Function in Skeletal Muscle of Acute Adiponectin Knockout Mice - Steven Medarev* (Florida State University College of Medicine), Madikay Faal, Andy Asher, Cole Smith, Muhammad Qasim, Jasen Belenko, Dylan Hendrickson, Logan Mitchell, Jayden Ojah-Maharaj, Victor Faynberg, Nicole Cannon, Judy Muller-Delp.
Nitric oxide-mediated vasodilation in tibial bone in young healthy individuals - Adina Draghici* (Harvard Medical School|Spaulding Rehabilitation Hospital), Matthew Ely, J. Andrew Taylor.
Systemic Mapping of Organ Plasma Extravasation Post Myocardial Infarction - Oliver Kitzerow* (University of Nebraska Medical Center), Paul Suber, Shukry Mohanad, Irving Zucker, Hanjun Wan.

Friday, April 21 - Poster Session with Wine and Cheese

The Microcirculatory Society posters and late-breaking posters will be featured on April 21, 2023 in the PhysioHub. Posters should be hung by 9:00 AM. The presentation time will be from 5:00 PM – 6:30 PM. Posters must be removed by 7:00 PM.

Please also visit the MCS Booth (#503) located in the PhysioHub! Bring your friends who may be interested in joining!

The Microcirculatory Society Pre-Meeting Session at the American Physiology Summit 2023

MCS Pre-Meeting Sessions: April 20, 2023 8:00 AM - 4:00 PM

American Physiology Summit Sessions: April 20, 4:00 PM - April 23, 12:30 PM

MCS Pre-Meeting Program:

Thursday, April 20 - All MCS Symposia will be held in Ballroom II of the Long Beach Convention Center.

8:00 – 9:30: Emerging Topics in Microcirculation

Chairs: Erika Boerman (University of Missouri) and Andreas Beyer (Medical College of Wisconsin)

Capillary pericytes as metabolic sentinels in the control of brain blood flow. Tom Longden, University of Maryland School of Medicine

Modulation of the lymphatic vasculature in progression of liver pathogenesis. Sanjukta Chakraborty, Texas A&M University Health Science Center

3D Wall Shear Stress Characteristics in Angiogenic Microvascular Networks through Red Blood Cell-Resolved Modeling. Peter Balogh, New Jersey Institute of Technology

Perivascular adipose tissue drives vascular dysfunction in inflammatory bowel disease. Erika Boerman, University of Missouri

Renal lymphatics and their impact on kidney inflammation. Joseph Rutkowski, Texas A&M University Health Science Center

15-minute break

9:45 – 11:15: Gabor Kaley Award Featured Topic: Endothelial Cell Biology in Health and Disease

Chair: Patricia D’Amore

MiR-433-3p Inhibition Alleviates Increased Endothelial Cell Permeability in Diabetes. Anita Kovacs-Kasa, Augusta University Health

Impact of PCSK9 on endothelial efferocytosis in vascular aging. Zufeng Ding, University of Arkansas for Medical Sciences

The impact of aging on pulmonary microvascular endothelial cell barrier function. Aminmohamed Manji, Western University

Endothelial expression of iron transporters is dependent on contact with smooth muscle. Luke Dunaway, University of Virginia

Attenuated hyaluronan synthesis impairs glycocalyx integrity and leads to arterial dysfunction. Jisok Lim, University of Utah

Skeletal muscle-derived extracellular vesicles contribute to post-exercise hypotension. Anjali Bhat, University of Nebraska Medical Center

90-minute break for lunch

12:45 – 2:15: President’s Symposium: Micro-Lymphatics as Mediators of Tissue Homeostasis

Chairs: Jerome Breslin (University of South Florida) and Pooneh Bagher (University of Nebraska Medical Center)

The Role of Epsins and MiR22 in Lymphatic Development and Disease. Hong Chen, Harvard Medical School

Obesity and Lymphatic Dysfunction: Structural and Molecular Modifications. Jorge Castorena, Tulane University

Lymphatics, Blood Vessels, Tissue Engineering, and Cancer: Connections in the Microcirculation. W. Lee Murfee, University of Florida

15-minute break

2:30 - 4:00: MCS Trainee Flash Talks: The Microcirculation From Head to Toe

Chairs: Frankie Hu (University of Florida), Jamie Meegan (Vanderbilt University Medical Center), Reetu Singh (Texas A&M University), Liping Zhang (University of Missouri)

Presentations listed below. Speakers marked *.

Regulation of Blood-Brain Barrier Endothelial Cell Hyperpermeability by NLRP3 Inflammasome Inhibition - Aliyah Anderson* (Morehouse School of Medicine), O'lisa Yaa Waithe, Saravanakumar Muthusamy, Gabriela Seplovich, Oluwatoyin Olagunju, Binu Tharakan.

Role of potassium ion diffusion from neurons to capillaries in neurovascular coupling: effects of astrocytic endfeet geometry - Sara Djurich* (University of Arizona), Timothy Secomb.

Homocysteine-induced Barrier Dysfunction and Hyperpermeability in the Blood-Brain and Blood-Retinal Barrier: Role of NLRP3 Inflammasome Pathway - O'Lisa Yaa Waithe* (Morehouse School of Medicine), Saravanakumar Muthusamy, Aliyah Anderson, Travis Hein, Ed Childs, Binu Tharakan.

Regulation of endothelial cell mitochondrial phenotype by mechanosensitive ion channel TRPV4 - Kesha Dalal* (The University of Toledo), Venkatesh Katari, Sailaja Paruchuri, Charles Thodeti.

Upregulation of endothelial DRP1 promotes a pathological vasodilation mechanism in response to flow-induced dilation - Cristhian Gutierrez Huerta* (Medical College of Wisconsin), Erin Birch, Shelby Hader, Amanda LeBlanc, David Guterrman, Andreas Beyer.

Cell-free hemoglobin-mediated oxidation of low-density lipoprotein (oxLDL) contributes to lung microvascular endothelial dysfunction during sepsis - Jamie Meegan* (Vanderbilt University Medical Center), Lorraine Ware, Julie Bastarache.

Creating the Phenotype of Preeclamptic Endothelial Dysfunction in Placental Vessels - Rosinda De La Pena* (Medical College of Wisconsin), David Gutterman, Curt Sigmund, Jennifer McIntosh.

Three-Dimensional Shear Stress Characteristics in Angiogenic Microvascular Networks Revealed Through Red Blood Cell-Resolved Modeling Based on Real Image Data - Mir Md Nasim Hossain* (New Jersey Institute of Technology), Nien-Wen Hu, Walter Murfee, Peter Balogh.

Short-chain fatty acids of the intestinal microbiota reduce mesenteric lymphatic pumping - Reetu Singh* (Texas A&M University), Cristine Heaps, Mariappan Muthuchamy, Randolph Stewart, Glen Laine, Ranjeet Dongaonkar.

Nitric oxide-mediated vasodilation in tibial bone in young healthy individuals - Adina Draghici* (Harvard Medical School|Spaulding Rehabilitation Hospital), Matthew Ely, J. Andrew Taylor.

Systemic Mapping of Organ Plasma Extravasation Post Myocardial Infarction - Oliver Kitzerow* (University of Nebraska Medical Center), Paul Suber, Shukry Mohanad, Irving Zucker, Hanjun Wan.

Friday, April 21 - Poster Session with Wine and Cheese

The Microcirculatory Society posters and late-breaking posters will be featured on April 21, 2023 in the PhysioHub. Posters should be hung by 9:00 AM. The presentation time will be from 5:00 PM – 6:30 PM. Posters must be removed by 7:00 PM.

Please also visit the MCS Booth (#503) located in the PhysioHub! Bring your friends who may be interested in joining!

American Physiology Summit Website Link

Poster Guidelines Link

2023 MCS Pre-Meeting Session Organizers (in alphabetical order):

Andreas Beyer – Medical College of Wisconsin

Erika Boerman – University of Missouri

Jerome Breslin – University of South Florida

Sanjukta Chakraborty – Texas A&M University Health Science Center

Osama Harraz – University of Vermont

Frankie Hu – University of Florida

Julie Leonard-Duke – University of Virginia

Jamie Meegan – Vanderbilt University Medical Center

Galina Mironova – University of Western Ontario

W. Lee Murfee – University of Florida

Joseph Rutkowski – Texas A&M University Health Science Center

Janaka Senarathna – Johns Hopkins University

Reetu Singh – Texas A and M University

Sonia Taib – Toronto General Hospital Research Institute

Sara Nunes Vasconcelos – University of Toronto

Camilla Wenceslau – University of South Carolina

Sherry Yang – University of South Florida

Liping Zhang – University of Missouri