July 2021 Featured Lab - Pooneh Bagher
Pooneh Bagher, Ph.D.
Department of Medical Physiology
Texas A&M University Health Science Center
Regulation of blood flow is required to maintain tissue perfusion throughout the body in proportion to metabolic demand. Resistance arterioles, comprised of vascular smooth muscle cells (SMCs), endothelial cells (ECs) and perivascular nerves (PVNs), are the primary site of regulation, with subtle changes in diameter resulting in significant alterations in flow. The main goal of our laboratory is examining the subtle interplay between ECs, SMCs and PVNs using a range of in vivo and in vitro techniques in normal and disease states. We are also interested in how vascular function is altered under extreme physiological conditions (like spaceflight!).
Top lesson you have learned in your career:
Be yourself. If you succeed, you succeed your way. If you fail, at least you know that you were always authentically yourself.
R Mitchell, NE Frederick, ER Holzman, F Agobe, HCM Allaway, and P Bagher. (2021) Ifetroban Reduces Coronary Artery Dysfunction in a Mouse Model of Duchenne Muscular Dystrophy. American Journal of Physiology- Heart and Circulatory Physiology. (available online)
A Mittal, PD Park, R Mitchell, H Fang, and P Bagher. (2021) Comparison of adrenergic and purinergic receptor contributions to vasomotor responses in mesenteric arteries. Journal of Vascular Research. 58 (1): 1-15.
NE Frederick, R Mitchell, TW Hein, and P Bagher. (2019) Morphological and pharmacological characterization of the porcine popliteal artery: A novel model for study of lower limb arterial disease. Microcirculation. 26 (6): e12527.