Dr. Thodeti’s current research focus is on the mechanical control endothelial cell function, angiogenesis and stem cell differentiation. Cells within all living tissues encounter mechanical forces continuously within a changing dynamic environment, and increasing evidence suggests that mechanical forces regulate cell growth, differentiation, motility, protein synthesis and gene expression. Importantly, mechanical forces are critical regulators of cardiovascular physiology and pathophysiology. Therefore, understanding how cells sense and convert mechanical signals into biochemical signals, mechanotransduction, could offer novel therapeutic targets for treatment of various cardiovascular diseases and in vitro engineering of organs and tissues such as blood vessels. Recently his laboratory has paid special attention to the role of a mechanosensitive ion channel, TRPV4, and its potential involvement in cardiac remodeling and pathological angiogenesis in the retina and in tumors.
Dr. Thodeti is an Assistant Professor in the Department of Integrative Medical Sciences, Northeast Ohio Medical University (NEOMED). He obtained his Ph.D. in Physiology and Biochemistry from S.V. University, India. He then completed post-doctoral training at Lund University, Sweden and later held a research faculty position at the University of Copenhagen, Denmark. Before joining NEOMED, Dr. Thodeti was an instructor at Harvard Medical School. He has published more than 50 peer-reviewed articles in the fields of cardiovascular physiology, cell and molecular biology, and biochemistry. Currently, his laboratory is supported by funds from the National Institutes of Health and American Heart Association. He also currently serves as an editorial board member for Circulation Research, Scientific Reports and the Journal of Cancer Science and Therapy.
Posted February 13, 2017