Newsletter Issue: Nov-Dec 2015
from Volume 22 Issue 8 - (pages 711-723)
Driving the Hypoxia-Inducible Pathway in Human Pericytes Promotes Vascular Density in an Exosome-Dependent Manner
Featuring: Jamie N. Mayo and Shawn E. Bearden, Idaho State University
In our recent study (Microcirculation, 22: 711-723) using human CNS cells and an ex vivo model of spinal cord injury, we found that HIF pathway activation is a possible molecular switch that induces pericytes to become pro-angiogenic. Although the mechanisms are still not clear, pericyte promotion of greater endothelial cord formation in collagen matrices and greater vessel density in spinal cord tissue was dependent on exosome signalling (signalling through small vesicles that are released from cells). We are currently working to determine if HIF pathway activation in pericytes can enhance vessel density in vivo. Understanding the mechanisms by which pericytes can become pro-angiogenic could aide in the development of novel therapeutic strategies to promote greater recovery after CNS injury.
Read the abstract.